LPS induces inflammatory chemokines via TLR-4 signalling and enhances the Warburg Effect in THP-1 cells.
The Warburg Effect has emerged as a potential drug target because, in some cancer cell lines, it is sufficient to subvert it in order to kill cancer cells.It has also been shown that the Warburg Effect occurs in innate immune cells upon infection.Innate immune cells play critical roles in the tumour microenvironment but the Warburg Effect is not He